Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study
Status:
Unknown status
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
This is a pilot study. The objective is to further understand the mechanism by which
amantadine improves function in patients with persistent vegetative state and minimally
conscious state. Specifically, the investigators will measure the size of the nerve fibers
that mediate arousal (reticular activating system, or RAS) pre and post treatment on MRI
tractography. MRI findings will be correlated with the Disability Rating Scale (DRS) score.
The information gathered from this study will be used to formulate a larger clinical trial.