Amantadine Sulphate Usage in Spine Deformities Corrective Surgeries Patients

• Status: Completed
• Trial end date: 2019-12-30
• Target enrollment: 0
• Participant gender: All

Summary

During the surgical procedure of scoliosis correction, large surgery extent and long-lasting strong nociceptive stimulation lead to postoperative pain formation of greater intensity compared with other orthopedic interventions. In these patients, duration of postoperative symptoms is longer, and may lead to persistent pain formation due to developing neuroplastic changes in the central nervous system.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Amantadine

Criteria

Inclusion Criteria:

1. Being candidate for spine deformity correction surgery(scoliosis and kyphosis )

2. Willing to participate in the study

Exclusion Criteria:

1. Patient refusal

2. Patients with chronic kidney, lungs,Gastrointestinal tract, liver, or cardiovascular diseases.

3. Pregnant or breastfeeding women.

4. Allergy to any of the study medications and taking medications that could significantly interact with amantadine (tramadol, atropine,antipsychotic medications)