Alternative Prophylaxis in Female Recurrent Urinary Tract Infections
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Urological pathogens are effected by rising antimicrobial resistance rates due to the
frequent use of antimicrobials for treatment and prophylaxis. Intravesical instillation with
hyaluronic acid (HA) and chondroitin sulphate (CS) obtained positive outcomes in the
treatment of overactive bladder, radiation cystitis and interstitial cystitis by
replenishment of the glycosaminoglycan layer of the bladder. This study is to investigate
whether intravesical instillation with HA-CS in patients with recurrent urinary tract
infections (rUTI) is superior to a placebo instillation in terms of reduction of rate of
symptomatic urinary tract infections (UTIs) (based on clinical diagnosis) needing treatment
with antimicrobials within 12 months after randomisation.