Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Diethylcarbamazine (DEC) essentially a micro-filaricidal drug is given for 12 days as
standard treatment for the clearance of W. bancrofti infection. It takes about one year for
the individuals to completely clear the microfilaria from the blood. It takes another two to
four years to clear the antigen. The aim of the present study is to shorten the time taken
for clearing the Mf and antigen from the blood either by co-administration or sequential
administration of a macrofilaricidal drug, Albendazole or doxycycline. This study is a
randomized, double blind, controlled clinical trial to study the efficacy of these drug
combinations in complete clearance the Mf and antigen from the blood in shorter span of 180
days and 365 days respectively.