Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis
Status:
Completed
Trial end date:
2018-12-28
Target enrollment:
Participant gender:
Summary
Symptoms of periodontal disease are tissue destruction and destruction of the alveolar bone
which supports the tooth. Wnt way (wingless-type MMTV integration site family) plays a role
in the regulation of bone homeostasis in periodontal disease-induced bone resorption. The Wnt
/ β-catenin signal is controlled by physiological antagonists, including dickkopf released
from osteocytes-associated protein 1 (DKK-1) and sclerostin (SOST). Thus, Wnt inhibitors SOST
and DKK-1 affect bone mass changes. Bisphosphonates used in osteoporous treatment are
selective inhibitors of bone resorption. In the serum of postmenopausal osteoporotic women
treated with bisphosphonate, short-term and decreased DKK-1 level during the treatment, and
increased SOST in the late period were reported. Increased bone formation after
bisphosphonate treatment in postmenopausal osteoporotic patients has been associated with
increased serum SOST level. The aim of our study is to investigate the effect of
bisphosphonate in patients with post-menopausal osteoporosis on the bone demolition
metabolism in periodontally healthy and periodontally diseased tooth regions and gingival
health with the clinical data by investigating the SOST and DDK-1 molecules that play role in
bone destruction mechanism.