Alpha Lipoic Acid as an Adjuvant Treatment in Acute Phosphide Poisoning

• Status: Unknown status
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate efficacy and safety of Alpha Lipoic Acid(ALA) as an adjuvant in the management of patients with acute phosphide poisoning.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Heba Allah Ali Abd El-Halim Mabrouk
• Collaborator: Tanta University
• Treatments: Thioctic Acid

Criteria

Inclusion Criteria:

Patients (male or female, aged 12 years or older) with symptomatic acute phosphide poisoning (deliberate or accidental), with diagnosis made on the basis of:

1. The typical clinical manifestations due to and following shortly after a single exposure to phosphide.

2. Reliable identification of the compound based on the container brought by patient attendants or a subsequent confirmation by silver nitrate test for phosphine detection in stomach contents.

Exclusion Criteria:

• Patients less than 12 years of age

• Pregnant and lactating women

• Patients with ingestion or exposure to other substances in addition to phosphide.

• Patients with other major medical conditions (e.g. cardiovascular disease, renal or hepatic failure).

• Patients presenting more than 6 hours of having consumed the phosphide compound (late presenters).

• Patients treated for acute phosphide poisoning in any medical center before admission.