Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide
Status:
Terminated
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to learn more about why most patients with early stages of
kidney disease have high blood pressure.
We know the body produces natural substances that cause blood vessels to open wider to carry
more blood when needed. An example is during exercise. Other natural substances cause blood
vessels to get smaller and slow down blood flow when needed. An example is when people are
cold. The balance between these substances is important. People with kidney disease and high
blood pressure do not have the normal balance of these substances.
This study will include 3 groups of people, people with normal blood pressure, people with
high blood pressure and people with kidney disease.
- Subjects will have a screening physical examination, including an ECG and laboratory
tests
- Subjects with high blood pressure may not take their regular blood pressure medication
for 3 weeks prior to the inpatient GCRC study
- Subjects will be given intra-arterial medications that will cause changes in the blood
vessels during the in-patient study.
The study will then compare the responses of the three groups. A GFR test will be done to
confirm the renal function of the group with chronic kidney disease.
These studies will provide insight into the mechanisms of the pathogenesis of enhanced α1
vasoreactivity in subjects with progressive renal disease. This will lay the groundwork for
new strategies in the treatment and prevention of vascular disease among the rapidly growing
group of individuals with CKD.
Phase:
N/A
Details
Lead Sponsor:
University of Michigan
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)