Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy
Status:
Terminated
Trial end date:
2019-05-08
Target enrollment:
Participant gender:
Summary
RATIONALE: A peripheral stem cell transplant may be able to replace blood-forming cells that
were destroyed by chemotherapy and radiation therapy, or that have become cancer. Sometimes
the transplanted cells from a donor can make an immune response against the body's normal
cells. Giving cyclophosphamide and fludarabine together with total-body irradiation followed
by cyclosporine and mycophenolate mofetil before the transplant may stop this from happening.
PURPOSE: This clinical trial is studying how well giving combination chemotherapy together
with radiation therapy followed by cyclosporine and mycophenolate mofetil works in treating
patients who are undergoing a donor stem cell transplant for hematologic cancer, metastatic
breast cancer, or kidney cancer.