Alleviation of Cedar Pollen Induced Allergic Symptoms by Orally Taken Superfine Beta-1,3-Glucan

• Status: Terminated
• Trial end date: 2004-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Intravenous- injection of beta-1,3-glucan in human is known to induce T helper type 1 response, while oral uptake did not. It was examined whether superfine dispersed beta-1,3-glucan (SDG) contrived to absorbed by intestinal mucosa would alleviate allergic symptoms by per-oral ingestion

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Meiji University of Oriental Medicine
• Collaborator: Kyoto Prefectural University of Medicine
• Treatments: Beta-1,3-glucan

Criteria

Inclusion Criteria:

• history of seasonal allergic conjunctivitis with or without rhinitis in spring (Japanese cedar pollen season) every year

• positive allergen specific IgE (> 30 IU/ml) or positive skin prick test result (wheal diameter > 3mm) to Japanese cedar, Orchard Grass pollen, or house dust-mite extract

Exclusion Criteria:

• Patients who had undergone immunotherapy in the previous 5 years

• a history of other immunological or medically relevant diseases