Algorithm Guided Treatment Strategies for Major Depressive Disorder

• Status: Unknown status
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare treatment outcomes between measurement based Algorithm Guided Treatment and Treatment As Usual strategies in a Chinese population with major depressive disorder.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Mental Health Center
• Treatments: Bupropion; Citalopram; Dexetimide; Duloxetine Hydrochloride; Fluoxetine; Fluvoxamine; Mianserin; Mirtazapine; Paroxetine; Sertraline; Trazodone; Venlafaxine Hydrochloride

Criteria

Inclusion Criteria:

• Meets Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for single or recurrent nonpsychotic major depressive disorder

• Age 18-75

• Written informed consent completed

• Scores 14 or higher on the 17-item Hamilton Depression Rating Scale

• Initial treatment with escitalopram or mirtazapine or other antidepressants is clinically appropriate

Exclusion Criteria:

• History of bipolar disorder

• Concurring psychotic disorders

• Scores 3 or higher on item 3 (suicidal) of HRSD-17

• History of nonresponse to an adequate trial of escitalopram and/or mirtazapine

• Has general medical condition, which contraindicates any leve 1 or 2 treatment option

• Is on concomitant medication, which contraindicates any leve 1 or 2 treatment option

• Any contraindication for mECT or rTMS

• Is pregnant or breast feeding or is planning to get pregnant