Aldosterone and Vascular Disease in Diabetes Mellitus
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
Specific aims for this proposal are to determine in patients with diabetes mellitus the
effects of an aldosterone receptor antagonist on:
1. Coronary microvascular function assessed by MRI perfusion reserve,
2. Endothelial dysfunction assessed by brachial artery reactivity studies, and
3. Inflammation assessed by blood measurements of c-reactive protein (CRP), monocyte
chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1).