Overview

Aldosterone Blockade to Prevent Myocardial Remodeling In Patients With Controlled Essential Hypertension

Status:
Terminated
Trial end date:
2011-09-01
Target enrollment:
0
Participant gender:
All
Summary
The goal of this project is to investigate the effects that the addition of aldosterone blockade with eplerenone will have on the progression of diastolic dysfunction in patients with controlled essential hypertension.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Creighton University
Treatments:
Eplerenone
Criteria
Inclusion Criteria:

- Treated and controlled hypertension

- Less than 140/90 in non-diabetics

- Less than 130/80 in diabetics

Exclusion Criteria:

- currently receiving an aldosterone blocker

- clinical evidence of congestive heart failure

- prior myocardial infarction

- renal dysfunction with a creatinine clearance of less than 40ml/min

- serum potassium > 5.5meq/L at initiation

- concomitant use of a medication that inhibits the CYP3A4 enzyme (ketoconazole,
itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir)