Aldosterone Blockade Early After Acute Myocardial Infarction
Status:
Completed
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
Study hypothesis : An early blockade of aldosterone receptors initiated at the first medical
contact after acute myocardial infarction may reduce major cardiovascular events within 6
months after the occurrence of the myocardial infarction.
Primary efficacy criterion : The 6 month rate of the composite of death, resuscitated cardiac
arrest, potentially lethal ventricular arrhythmia, indication for implantation of an
implantable cardioversion device, occurrence or aggravation of heart failure.
Primary objective: To demonstrate the superiority of aldosterone blockade initiated as soon
as possible within 72 hours after the onset of acute myocardial infarction on top of standard
therapy, compared to standard therapy alone, with or without reperfusion therapy.
Study design : Prospective, multi-centre randomised, open labeled with 2 parallel study arms.