Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine

• Status: Withdrawn
• Trial end date: 2019-04-12
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study will aim to determine if adding phenobarbital or ketamine to a symptom-triggered benzodiazepine regimen decreases the rate of intensive care unit admissions during the treatment of alcohol withdrawal syndrome when compared to symptom-triggered benzodiazepine therapy alone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Santa Barbara Cottage Hospital
• Treatments: Ketamine; Lorazepam; Phenobarbital

Criteria

Inclusion Criteria:

• Primary admitting diagnosis of acute alcohol withdrawal syndrome based on International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10), code F10.3, F10.4.

Exclusion Criteria:

• Significant comorbid medical illness requiring Intensive Care Unit admission;

• Pregnancy;

• Inability to obtain intravenous access;

• Child Pugh Class C; and

• Allergy to study medications (phenobarbital, ketamine, lorazepam).