Albumin and Crystalloid Administration in Septic Shock
Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The current guideline emphasizes fluid resuscitation as the mainstay of initial management
for septic shock. Albumin has the oncotic activity to maintain intravascular volumes with
additional beneficial properties in sepsis. Prior studies showed that the replacement of
albumin might have survival advantages in patients with septic shock. We aim to assess
whether the early administration of albumin with crystalloid as initial fluid resuscitation
improves survival in patients with septic shock compared to resuscitation without albumin.
Phase:
Phase 4
Details
Lead Sponsor:
Asan Medical Center
Collaborators:
Chungnam National University Hospital Gangnam Severance Hospital Hanyang University Korea University Korea University Guro Hospital Samsung Medical Center Seoul National University Bundang Hospital Seoul National University Hospital SMG-SNU Boramae Medical Center