Overview

Aggressive Intravenous Hydration With or Without Indometacin to Prevent Pancreatitis After Pancreatic Extracorporeal Shock Wave Lithotripsy

Status:
NOT_YET_RECRUITING

Trial end date:
2027-12-01

Target enrollment:

Participant gender:

Summary

This study aims to determine whether combining aggressive intravenous hydration with indometacin is more effective at preventing pancreatitis after a Extracorporeal Shock Wave Lithotripsy (ESWL) than using indometacin alone. The study will involve patients who are scheduled to undergo ESWL for pancreatic stones. Participants will be randomly assigned to one of two groups: one will receive both the intravenous hydration and the rectal indometacin, while the other will receive only the rectal indometacin. The trial will be conducted at multiple centers, ensuring a broad and diverse patient population. The primary outcome of the study will be the incidence of pancreatitis after the ESWL procedure. This study is important because it could lead to a better understanding of how to prevent pancreatitis after ESWL, potentially improving patient outcomes and reducing the risk of serious complications.

Phase:

Details

Lead Sponsor:

Changhai Hospital

Collaborators:

Affiliated Hospital of Yunnan University
First Affiliated Hospital of Lanzhou University
First People's Hospital of Hangzhou
Peking Union Medical College Hospital
Qilu Hospital of Shandong University
Ruijin Hospital
Shanghai Pudong New Area Gongli Hospital
The Second Affiliated Hospital of Baotou Medical College
The Third Xiangya Hospital of Central South University

Treatments:

Ringer's Lactate
Saline Solution