Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease

• Status: Unknown status
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare two current first-line treatments for childhood Crohn's Disease, steroids versus a liquid diet, and determine the effects of these treatments on bone health, quality of life and treatment efficacy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Birmingham
• Collaborators: Children's Memorial Research Foundation; SHS International; St George's University Hospital Research Foundation
• Treatments: Glucocorticoids; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Active Crohn's Disease with PCDAI > 20

• Aged 7 - 17 with possibility of 1 year follow-up

Exclusion Criteria:

• Previous treatment for Crohn's Disease with liquid diet or glucocorticoid therapy

• Isolated orofacial granulomatosis

• Intravenous glucocorticoid therapy immediately indicated

• Planned surgical intervention for CD