Overview

Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function

Status:
Unknown status
Trial end date:
2009-05-01
Target enrollment:
0
Participant gender:
All
Summary
Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low arterial pressure) and high levels of pro-inflammatory cytokines. Hydrocortisone has been shown to have a beneficial effect on clinical outcome. The aim of this study is to evaluate the incidence of RAI in the different settings of ascites in cirrhosis and the usefulness of hydrocortisone in this context.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Turin, Italy
Treatments:
Cortisol succinate
Epinephrine
Epinephryl borate
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Pharmaceutical Solutions
Racepinephrine
Criteria
Inclusion Criteria:

- Cirrhosis with ascites, with or without hepatorenal syndrome

Exclusion Criteria:

- Age < 18 and > 75 years

- Shock or bacterial infection present at the inclusion or during the previous week

- Bleeding present at the inclusion or during the previous week

- Multifocal HCC

- Organic renal failure

- Hearth or pulmonary failure