Overview

Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease

Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
0
Participant gender:
All
Summary
We aimed to evaluate the hypothalamus-pituitary-adrenal axis in autosomal dominant polycystic kidney disease (ADPKD) patients. Twenty two ADPKD patients and 27 healthy subjects were enrolled.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Istanbul University
Treatments:
Cosyntropin
Epinephrine
Epinephryl borate
Racepinephrine
Criteria
Inclusion Criteria:

- Healthy subjects

- Diagnosis of autosomal dominant polycystic kidney disease

Exclusion Criteria:

- A glomerular filtration rate below 60 ml/min

- History of recent major surgery

- Systemic infections with fever

- Significant hirsutism (Ferriman Gallwey scoreā‰„8)

- Congenital adrenal hyperplasia

- Late onset congenital adrenal hyperplasia

- Systemic corticosteroid use (including previous use)

- Topical corticosteroid use

- Menstrual irregularity

- History of thromboembolism

- Uncontrolled diabetes or hypertension

- History of psychosis

- Pregnancy

- Lactation

- History of hypersensitivity to tetracosactin