Adrenal Cortical Function and Vitamin A Deficiency in Sepsis
Status:
Completed
Trial end date:
2000-01-01
Target enrollment:
Participant gender:
Summary
The study involves the participant to receive a 250 mcg Cortrosyn (ACTH) Stimulation Test to
test the ability of the body to make Cortisol. If the body is not able to make large amount
of Cortisol (Delta Cortisol < 13 mg/dl) from the stimulation test, then the participant will
be given additional cortisol like medicine called Solumedrol or matching placebo.
If the body is able to make large amounts of Cortisol (> 13 mg/dl), then the participant will
receive daily shots of Vitamin A for 7 days or matching placebo.
If the participant does not respond to the stimulation test, and meets the criteria for
Cortisol deficiency (all 3 cortisol concentrations < 20 mg/dl), then he/she will screen
failed for the study and will be offered hydrocortisone as part of routine care by the
treating physician.
Phase:
Phase 4
Details
Lead Sponsor:
Los Angeles Biomedical Research Institute Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center