Administration of Single High Dose Letrozole for Ovulation Induction

• Status: Completed
• Trial end date: 2020-07-31
• Target enrollment: 0
• Participant gender: Female

Summary

Letrozole is considered an established treatment for ovulation induction.The most common protocol is daily dose of 2.5-7.5 mg starting day 3-5 of the cycle for 5 days.Another described protocol is single high dose 20mg Letrozole given on day 3 of the cycle.

Our aim is to compare the single high dose Letrozole protocol to daily low dose protocol.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mount Sinai Hospital, Canada
• Treatments: Letrozole

Criteria

Inclusion Criteria:

• Polycystic ovary syndrome (PCOS) patients

• BMI (body mass index) of 18-35.

• Proved one patent fallopian tube at least

Exclusion Criteria:

• Women with low ovarian response (According to Bologna criteria )

• Blocked fallopian tubes

• Pregnancy

• Presence of any clinically significant health problem such that treatment with letrozole or pregnancy would not be in the subject's best interest.

• Co-administration of other anti-estrogens

• Hypersensitivity to Letrozole .