Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
Primary objective :
- To explore the relation between 3 doses of GRASPA and duration of asparagine depletion
(< 2µmol/l)
Secondary objective :
- Pharmacokinetic / Pharmacodynamic parameters
- toxicity
- Study duration : 2 years
- Study treatment : Red blood cells loaded with L asparaginase versus native L
asparaginase
- Associated treatments : COPRALL chemotherapy
- Randomization : centralised randomisation on scratching list