Administrating Oxytocin to Treat Treatment Schizophrenia and Schizo-affective Patients
Status:
Unknown status
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
The objectives of the study are:
1. To evaluate the effect of OT compared to placebo, as add-on to anti-psychotics, on
social functioning in schizophrenia.
2. To evaluate the effect of socially oriented CBT administered to patients immediately
after they receive OT, compared to patients who receive OT with not-socially oriented
CBT, and compared to patients who receive socially oriented CBT without OT. The
investigators hypothesize that OT and socially oriented CBT will have a synergistic
effect, and will be better than OT or CBT alone.
3. Use a detailed, in depth analysis of social interaction to assess these putative effects
of OT. The investigators hypothesize that the use of this analysis will show larger
treatment effects of OT than previously shown in less sensitive assessments, such as
PANSS.
4. To assess the effect of epigenetic status on response to OT. The investigators
hypothesize that epigenetic variants associated with lower OT plasma levels will be
associated with greater response to OT treatment.
5. To assess in the relationships between levels of salivary OT and vasopressin, and social
interactions in schizophrenia.
6. To assess in the relationships between levels of salivary OT and vasopressin, and
response to OT treatment.