Adjuvant Oophorectomy and Tamoxifen in Premenopausal Women With Hormone Receptor-Positive Breast Cancer

• Status: Completed
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

This trial tests surgical oophorectomy (removal of ovaries) plus Tamoxifen, done at different times in the menstrual cycle, as adjuvant therapy for invasive breast cancer in 510 premenopausal women with Hormone Receptor-positive Breast Cancer. This study is recruiting at hospitals in Philippines, Vietnam, and Morocco.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: International Breast Cancer Research Foundation
• Treatments: Hormones; Tamoxifen

Criteria

Inclusion Criteria:

• Open for accrual in Asia only

• Female age 18-50,

• premenopausal with regular cycles (>25-35 in length)

• fine-needle aspiration diagnosis

• Stage II-IIIA hormone receptor positive invasive breast cancer

• No prior radiation or chemotherapy

• Must be surgical candidate for bilateral oophorectomy