Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD
Status:
Recruiting
Trial end date:
2022-08-30
Target enrollment:
Participant gender:
Summary
Around 7.2% of children around the world are suffering from ADHD. On account of current
medical treatment, a high remission rate can be reached for ADHD. Nevertheless, patients have
to face a number of side effects associated with the treatment. It was informed that patients
of ADHD have a tendency to vitamin A and vitamin D deficiency. The aim of the study is to
determine the effect of vitamin A and vitamin D supplementation as adjunctive therapy to
methylphenidate on symptoms of ADHD. 504 subjects aged 6-12 years with a diagnosis of ADHD
based on DSM-5 criteria are randomly assigned into three groups to receive vitamin A 6000
IU/day and vitamin D 2100 IU/day, or vitamin D 2100 IU/day or placebo adding to
methylphenidate for 8 weeks. Symptoms severity is assessed by Vanderbilt Assessment Scales
and Questionnaire - Children with Difficulties at weeks 0, 4, and 8. Serum levels of retinol
and 25(OH)D are measured at baseline and after 8 weeks. All the other sociodemographic data
are assessed. The study can give more references on the application of vitamin A and vitamin
D in addition to methylphenidate to ADHD. Future research is needed to clarify mechanism of
vitamin A and vitamin D on ADHD.
Phase:
Phase 4
Details
Lead Sponsor:
Chen Li
Treatments:
Ergocalciferols Methylphenidate Retinol palmitate Vitamin A Vitamin D Vitamins