The present study is a randomized open-label -phase III study that aims to compare the
efficacy of Zoladex® combined with Aromidex® for 3-2 years after SERMs (tamoxifen and
Fareston®) as an adjuvant therapy for 2-3 years with the efficacy of tamoxifen up to 5 years
for premenopausal breast cancer women with hormone receptor positive, lymph node positive or
tumor ≥4cm. According to St. Gallen's guideline, hormone receptor positive was defined as
endocrine responsive and endocrine response uncertain categories (table 3-1), and only those
with ER or PR expression undetectable were considered as HR negative. The pathological
evaluation of axillary lymph node could be done by sentinel node biopsy (SNB) when axillary
nodes were clinically impalpable accompanied with axillary lymph node dissection (ALND) or
directly through ALND when axillary nodes appeared to be positive in clinical examination.
Based on the operating standard of local medical institution, identifying the numbers of
lymph nodes to do the pathological evaluation and to do the dissection of I- or II-station
nodes accurately.