Adjustment of DOses of NIcotine in Smoking Cessation (ADONIS)

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Nicotine replacement therapies (NRT) have proven efficacy to help smokers quit. However, their effectiveness is low. This study aims to answer the question: Does the dose adjustment of NRT according the saliva concentration of nicotine's main metabolite: cotinine improve their efficacy compared with the lack of dose adjustment (usual care) in smoking patients with smoking related disease condition.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: French Health Products Safety Agency
• Treatments: Nicotine; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• Age ≥18 years Smoking ≥ 10 cigarettes per day Patients with disease conditions known to be related to smoking: e.g.coronary heart diseases, COPD, lower extremity arterial disease, etc

Exclusion Criteria:

• Smokers whose follow-up during the duration of the study, in a predictable way, cannot be assured.

• smokers having been treated by bupropion ( Zyban) during two months preceding the inclusion

• persons under TSN, neuroleptic, substitute treatments in OPINOIDES, under anticoagulants-non-equilibrating,

• encircled woman

• breast-feeding woman

• Contraindication usual of the TSN