Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair
Status:
Completed
Trial end date:
2006-07-01
Target enrollment:
Participant gender:
Summary
The durability of endovascular aneurysm repair (EVAR) has been limited by development of
endoleaks which may be secondary to progressive aortic degeneration by matrix
metalloproteases (MMP). Doxycycline is a known inhibitor of the MMP family of enzymes in
aneurysms. The investigators propose a randomized, controlled trial of adjuvant doxycycline
therapy with EVAR to determine its effects on re-intervention, aneurysm shrinkage and serum
markers of aneurysmal degeneration.
Phase:
N/A
Details
Lead Sponsor:
Barnes-Jewish Hospital The Foundation for Barnes-Jewish Hospital