Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults
Status:
Completed
Trial end date:
2018-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to describe the safety and efficacy of nitrous oxide
administration for pain and anxiety before propofol in patients requiring any procedure under
sedation in the Emergency Department. Procedural sedation is the use of sedative, analgesic,
and/or dissociative agents to relieve anxiety and pain associated with diagnostic and
therapeutic procedures. Propofol is commonly used and is a sedative and amnestic, but
provides no analgesia. Short acting opioids may be used for pain relief, but come with the
risk of respiratory depression. An optimum analgesic to relieve pain in patients who need
procedural sedation should be short acting, easy to administer and safe. Nitrous oxide may be
a suitable agent, but literature supporting or rejecting its use in adults is lacking. This
study aims to fill this gap. Adult patients capable of consenting, coming to the Emergency
Department with painful condition requiring procedural sedation are the targeted population.
Eligible patients who consent to the study will receive Nitrous Oxide gas delivered through a
hand held mask before they receive propofol for the procedure. Information regarding their
vitals, pain scores and medical condition will also be collected.