Overview

Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults

Status:
Completed
Trial end date:
2018-02-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to describe the safety and efficacy of nitrous oxide administration for pain and anxiety before propofol in patients requiring any procedure under sedation in the Emergency Department. Procedural sedation is the use of sedative, analgesic, and/or dissociative agents to relieve anxiety and pain associated with diagnostic and therapeutic procedures. Propofol is commonly used and is a sedative and amnestic, but provides no analgesia. Short acting opioids may be used for pain relief, but come with the risk of respiratory depression. An optimum analgesic to relieve pain in patients who need procedural sedation should be short acting, easy to administer and safe. Nitrous oxide may be a suitable agent, but literature supporting or rejecting its use in adults is lacking. This study aims to fill this gap. Adult patients capable of consenting, coming to the Emergency Department with painful condition requiring procedural sedation are the targeted population. Eligible patients who consent to the study will receive Nitrous Oxide gas delivered through a hand held mask before they receive propofol for the procedure. Information regarding their vitals, pain scores and medical condition will also be collected.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Albert Einstein Healthcare Network
Treatments:
Nitrous Oxide
Propofol
Criteria
Inclusion Criteria:

- Spontaneous respirations

- 18 years of age and older

- American Society of Anesthesiologists (ASA) Physical Status Classification 1 or 2, who
will be receiving sedation for an Emergency Department procedure.

- Ability to provide informed consent.

Exclusion Criteria:

- Comorbidities that affect ventilation, perfusion, or metabolism

- Intubated

- Cardiopulmonary instability

- Major trauma

- Sepsis

- American Society of Anesthesiologists (ASA) class 3, 4, and 5.

- Inability to provide informed consent

- Nursing home residents

- Age less than 18 years

- Non English speaking

- Pregnant women

- Under police custody