Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes
Status:
Not yet recruiting
Trial end date:
2032-12-31
Target enrollment:
Participant gender:
Summary
People with newly diagnosed type 2 diabetes treated with metformin that have not reached
their HbA1c target (49-64 mmol/mol) will be recruited to the study. If they fulfill the
inclusion and none of the exclusion criteria, they will be, after signing informed consent,
randomized to a six-month intervention with either pioglitazone, empagliflozin or
semaglutide. Fat biopsies are obtained from the subcutaneous abdominal area before and after
a hyperinsulinemic-euglycemic clamp at baseline and after six months. Participants are
regularly followed during this the intervention. The overall goal is to determine how
antidiabetic-drugs affect white adipose tissue cellularity and whether adipose heterogeneity
impacts on drug response. The primary outcome measure is the change in fat tissue lipolysis
(glycerol release in isolated fat cells after hormone stimulation) before and after
treatment.