Adipokines in Obese Adolescents With Insulin Resistance

• Status: Completed
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after three months treatment with metformin in obese adolescents with insulin resistance (IR).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Regional de Alta Especialidad del Bajio
• Collaborator: Hospital Infantil de Mexico Federico Gomez
• Treatments: Insulin; Metformin

Criteria

Inclusion Criteria:

• Obesity defined as Body Mass Index (BMI) ≥ percentile 95

• Tanner stage ≥ 2

• Insulin resistance defined as Basal insulin > 15 µU/mL or Homeostasis Model Assessment index (HOMA) > 4.5

• Patients' parents signed written consents when they and their adolescent children agreed to enroll

Exclusion Criteria:

• Glucose intolerance

• Diabetes mellitus (type 1 or 2)

• Anemia (Hb < 10 g/dL)

• Plasma creatinine > 1.4 mg/dL

• Abnormal hepatic function

• Any associated Disease (Pulmonary, Infection, Autoimmune Disease)

• History of lactic acidosis