Adenosine and A2A Receptors in Human Brown Adipose Tissue
Status:
Completed
Trial end date:
2016-06-30
Target enrollment:
Participant gender:
Summary
This study investigates the significance of adenosine and A2A receptors in human brown
adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the
density of A2A receptors will be measured in supraclavicular BAT and other tissues in healthy
men. The investigators hypothesize, that adenosine can activate BAT, and that adenosine A2A
receptor density changes when BAT is activated by cold exposure.
Understanding the mechanisms of BAT activation and the role of endocannabinoids in humans is
important and beneficial in fighting against the epidemic of obesity and diabetes.