Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache
Status:
Completed
Trial end date:
2024-01-03
Target enrollment:
Participant gender:
Summary
Postdural puncture headache (PDPH) is a major complication of neuraxial anesthesia that can
occur following spinal anesthesia and with inadvertent Dural puncture during epidural
anesthesia. The presence of Pyridostigmine in CSF would be expected to increase the level of
acetylcholine in CSF and subsequently in the brain through inhibition of cholinesterase. The
increased level of acetylcholine would produce cerebral vasoconstriction.