This study aims to build on previous work characterising the PK of penicillin-V to explore
the potential impact of probenecid on PK-PD target attainment. Achievement of the aims of
this study would provide data to support the design of experimental studies exploring the
clinical impact of probenecid on treatment outcomes and also provide a rationale for
exploration of probenecid's effects on a larger number of beta-lactam antibiotics.
Hypothesis: Addition of probenecid to oral phenoxymethylpenicillin (penicillin-V) has a
clinically relevant effect on pharmacokinetic-pharmacodynamic (PK-PD) target attainment.