Addition of Ondansetron to Ongoing Antipsychotic Treatment for Schizophrenia

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine the effects of ondansetron on auditory nerve activity in people with schizophrenia who are being treated with new antipsychotics.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Antipsychotic Agents; Ondansetron

Criteria

Inclusion Criteria:

• Meets DSM-IV criteria for schizophrenia

• Stable, chronic schizophrenia

• Currently taking atypical medications

• Use of effective form of contraception throughout study

Exclusion Criteria:

• History of any alcohol or drug abuse within 3 months of study start date

• Any other major neurological disorders

• History of or current head trauma

• Any medical conditions affecting the central nervous system

• Current epilepsy, asthma, migraine headache, previous myocardial infarction, stroke, diabetes, hypertension, narrow angle glaucoma, or neuromuscular illnesses

• Pregnant