Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty

• Status: Enrolling by invitation
• Trial end date: 2021-09-30
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective, cluster-randomized, two-arm, comparative study aimed at determining whether addition of tizanidine ( an oral muscle relaxant) to a multimodal pain regimen following primary TKA reduces opioid consumption.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rothman Institute Orthopaedics
• Treatments: Tizanidine

Criteria

Inclusion Criteria:

• - Patients undergoing unilateral primary TKA with underlying diagnosis of osteoarthritis.

• ASA I - III

• Spinal anesthesia

• All patients will have a total knee arthroplasty utilizing a medial parapatellar approach with cruciate sacrificing implants and patellar resurfacing. A tourniquet will be used in all cases.

• Men and women between 18 and 80 years who are willing and able to provide informed consent

Exclusion Criteria:

• Opioid use greater than 10 mg/day morphine equivalents continuously for one month within 3 months preoperatively

• Inability to take/allergy to the protocol medications

• Contraindication to regional anesthesia

• Non-English speaking

• ASA IV or greater

• Psychiatric or cognitive disorders

• Allergy/contraindications to protocol medications.

• Renal insufficiency with Cr > 2.0 or hepatic failure

• Sensory/motor disorder involving the operative limb

• PCS score >20

• Patients with severe cardiac or neurological conditions precluding the use of study medications

• Patients using anticoagulation other than aspirin for the 14-day period after discharge