Overview Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight Status: Completed Trial end date: 2013-05-01 Target enrollment: Participant gender: Summary This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight. Phase: Phase 4 Details Lead Sponsor: Washington University School of MedicineCollaborator: National Institute of Mental Health (NIMH)Treatments: MetforminSertraline