Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight

• Status: Completed
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Metformin; Sertraline

Criteria

Inclusion Criteria:

• Body mass index (BMI) greater than 28.7

• Positive screening for depression

• Must live within 100 miles of the St. Louis metropolitan area

Exclusion Criteria:

• Pregnant or breastfeeding

• Known hypersensitivity to sertraline or metformin

• Recent history of heart attack or unstable heart disease

• Severe liver disease or kidney impairment, defined by a serum creatine level above 3 mg/dL

• Psychiatric disorder thought to affect management, such as schizophrenia, or alcohol or drug dependence