Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD
Status:
Recruiting
Trial end date:
2025-05-01
Target enrollment:
Participant gender:
Summary
The current project will evaluate the efficacy of adding Written Exposure Therapy (WET) to a
course of repeated IV ketamine infusions in prolonging PTSD symptom improvement/time to loss
of response in patients with chronic PTSD). WET is a brief, 5-session evidence-based written
trauma-focused therapy without in between-session assignments, with demonstrated efficacy and
low dropout rates in patients with PTSD. WET will be administered to all eligible
participants; the first WET sessions will be interleaved with the last two ketamine infusions
to take advantage of a window of increased neuroplasticity potentially induced by repeated
ketamine infusions. WET will be administered on different days as the ketamine infusions.