Adding Nebulized Salbutamol to Intravenous Atropine and Oxygen in OP Poisoning
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
We hypothesize that salbutamol will speed removal of alveolar fluid compared to atropine
alone in OP poisoned patients. We propose to compare the effect of two stat doses of
nebulized salbutamol (2.5 mg; 5.0 mg), with nebulized saline placebo, in symptomatic patients
receiving standard resuscitation with atropine, oxygen, and fluids after poisoning with OP
pesticides. 25 patients will be randomised to each arm (total 75 patients). Primary outcome
will be oxygen saturation's over the following 60 min during resuscitation. Secondary
outcomes will include atropine dose administered, speed to stabilization, aspiration or
pneumonia, intubation, tachydysrhythmias, and mortality. A positive outcome will result in
design of a large definitive phase III study.