Overview Addictive Threshold of Nicotine Status: Recruiting Trial end date: 2027-01-30 Target enrollment: Participant gender: Summary To determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, -and reinforcement in smokers with different levels of dependence. Phase: Early Phase 1 Details Lead Sponsor: Yale UniversityCollaborator: National Institute on Drug Abuse (NIDA)Treatments: Nicotine