Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among prison
inmates with a history of opioid dependence. This includes: a) comprehensive TB diagnostic
study (symptom screening, chest x-ray, tuberculin skin test, acid-fast bacilli smear, Gene
Xpert, and sputum culture) to determine best practices for screening HIV+ and HIV- prisoners;
b) A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high
prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course
weekly isoniazid + rifapentine (12HR); and c) a 3-arm preference trial comparing post-release
TB treatment completion in patients on opioid agonist treatment (methadone vs naltrexone
implant) vs no opioid agonist treatment in patients being treated for active or latent TB who
are transitioning to the community. Investigators will also use this data, and publicly
available data to complete agent-based modeling for comparative and cost-effectiveness of
various TB screening and treatment strategies among prisoners, and upon community transition
post-release from prison.
Phase:
Phase 4
Details
Lead Sponsor:
Yale University
Collaborators:
National Institute on Drug Abuse (NIDA) University of Malaya
Treatments:
Buprenorphine Buprenorphine, Naloxone Drug Combination Isoniazid Methadone Naloxone Naltrexone Rifapentine