Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
Status:
Completed
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
The primary objective is to comparatively evaluate the isolated effects of a long-acting
beta2-adrenergic (formoterol fumarate 12µg b.i.d. via Aeroliser) and combined with a
long-acting anti-cholinergic (tiotropium bromide 18µg o.d via Handihaler) on breathlessness,
dynamic hyperinflation and exercise tolerance in patients with advanced, but stable, chronic
obstructive pulmonary disease. The study hypothesis is that combining long acting
bronchodilators with different action mechanisms would promote synergistic effects on
clinical outcomes.