Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus

• Status: Unknown status
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

the purpose of this study is to compare the efficacy and safety of a new method of corneal cross-linking that uses UV-A irradiation intensity of 9mW/cm2 for 7 minutes to well-known Accelerated corneal cross-linking (9 mW/cm2 UV-A irradiation for 10 minutes)

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tehran University of Medical Sciences
• Treatments: Dextrans; Riboflavin

Criteria

Inclusion Criteria:

• Mild to moderate progressive KCN (Grade I and II) based on Amsler-krumeich classification; progression is defined as the old fashioned way in the lack of a consensus for more modern methods that is increase of > 1D of Kmax readings within 12 months

• Age> 18 y, and <35 years

• Kmax lower than 58 D

• Signing informed consent form

Exclusion Criteria:

• Any other ocular disease

• Corneal scar

• History of hydrops

• Any other ocular surgery including previous CCL, corneal inlay or keratorefractive surgery

• Inability to complete follow up schedule