This proposed study is designed to compare the efficacy of interpersonal and social rhythm
therapy (IPSRT) alone to IPSRT plus medication as an acute treatment for bipolar II
depression. The investigators propose to conduct a randomized, controlled, trial comparing
the effects of IPSRT plus pill placebo to IPSRT plus quetiapine on depressive symptoms in
individuals suffering from Bipolar II depression. The investigators will also examine the
impact of treatment on psychosocial function.