Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Serum-creatinine level (s-Cr) is an important factor for predicting perioperative patient's
outcome regarding acute kidney injury. Although cardiopulmonary bypass (CPB), an essential
procedure for cardiac surgery, dilutes patient's blood components, possible impact of
applying acute normovolemic hemodilution (ANH) and CPB on s-Cr has not been well
investigated.
In patients undergoing cardiac surgery employing moderate hypothermic CPB (age 20-71 years,
n=32), ANH will be randomly applied to 15 patients (Group-ANH) but not in 17 patients
(Group-C) before initiating CPB. For ANH procedure consisting of 5 ml/kg of blood salvage and
administering 5 ml/kg of balanced hydroxyethyl starch (HES) 130/0.4 for 15 min will be
started at 30 min after anesthesia induction and before CPB application for surgery. In both
groups, moderate hypothermic CPB will be initiated by using 1600-1800 ml of bloodless priming
solution. The changes of hematocrit (Hct), Na+, K+, HCO3-, Ca2+, osmolarity, s-Cr will be
determined before ANH (T1), after the first ANH of 2.5 ml/kg (T2), and after the second ANH
of 2.5 ml/kg (T3), 30 sec and 60 sec after the initiation of CPB (T4, T5), immediately and 1
hour after the weaning from CPB (T6, T7) and at the end of surgery (T8). S-Cr will be
determined by using a point-of-care test device (StatSensor™ Creatinine, Nova Biomedical,
USA).