Dexmedetomidine (Precedex, Hospira) is a "super" selective alpha2-agonist - 8-10x more avid
binding to alpha2 receptors than clonidine - and may have particularly favorable
characteristics as a continuous i.v. infusion sedative for critically ill neuroscience
patients. Its combination of anxiolysis, analgesia, without undue lethargy may make it an
ideal agent where frequent neurological examinations are important. Unclear, however, is
whether Precedex is superior to current common i.v. sedation protocols, and if there are any
undue concerns of this agent on cerebral physiology and cortical stimulation.