Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium
Status:
Completed
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
The effects of acute administration of non-steroidal anti-inflammatory drugs (NSAIDs) on the
neuroendocrine regulation of hydro-electrolytic metabolism are not precisely known to date.
Although the mechanism by which NSAIDs favor the antidiuretic action of vasopressin (AVP) in
the kidney has been partially elucidated, their influence on the mechanisms responsible for
regulating its secretion are less known. The interactions between NSAIDs and natriuretic
peptides are also not entirely certain.
The present pharmacological research study therefore aims to investigate, in a cohort of
healthy subjects, the acute effects of intravenous infusion of diclofenac sodium on the
neuroendocrine regulation systems of water and salt balance (i.e. the antidiuretic axis and
the system of natriuretic peptides).
Phase:
Phase 4
Details
Lead Sponsor:
Azienda Ospedaliera Città della Salute e della Scienza di Torino