Estradiol promotes and maintains the typical female phenotype characterized by subcutaneous
fat accumulation. There is evidence to suggest that this effect relies on the ability of
estradiol to increase the amount of anti-lipolytic α2A-adrenergic receptors, but whether this
requires long-term exposure to estradiol or is the result of an immediate effect is not
clear. Objective: To study acute effects of a single dose (4 mg) of 17β-estradiol on regional
and systemic lipolysis.