Acute Mechanical Response to Anti-arrhythmic Drug Therapy

• Status: Withdrawn
• Trial end date: 2018-02-27
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine if anti-arrhythmic drugs with a sodium channel-blocking mechanism exert a detrimental electromechanical effect on cardiac function in patients depending upon baseline intraventricular conduction and left ventricular function.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Evan Adelstein, MD; University of Pittsburgh
• Collaborators: University of Pittsburgh; UPMC
• Treatments: Anti-Arrhythmia Agents; Procainamide

Criteria

Inclusion Criteria:

• Implanted cardiac device requiring generator change and a new device

• Able to give informed consent

Exclusion Criteria:

• Current membrane-active anti-arrhythmic

• Glomerular filtration rate (GRF)<30 milliliters (mL)/min

• MAP<60 mmHg

• Known intolerance to procainamide

• Pregnancy

• Age <18 or >85 years old

• Baseline QT interval >480 ms (500 ms if paced)