Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis
Status:
Completed
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Pulmonary hypertension is common in patients with aortic stenosis and is associated with
worse operative and long-term outcomes. Sildenafil has been shown to reduce pulmonary artery
pressure and improve exercise performance in patients with left-sided heart failure, but this
has not been tested in patients with aortic stenosis. We hypothesize that Sildenafil will
produce a clinically significant decrease in pulmonary artery pressure in patients with
severe aortic stenosis. The dose of Sildenafil that produces a significant decrease in
pulmonary artery pressure will be safe and well tolerated in patients with and without a
depressed ejection fraction.